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What is Hydrocodone 2.5/500mg ? Hydrocodone is a pain reliever that is used to treat chronic pain. Hydrocodone is an opioid analgesic, which means it relieves pain. It changes how your body perceives and responds to pain by acting on the brain. Do not use the extended-release type of Hydrocodone to treat pain that is minimal or will go away in a few days. This drug should not be used on a "as required" basis. What are the side-effects of Hydrocodone 2.5/500mg ? · It is possible to have nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness. After you've been taking this drug for a while, some of these adverse effects may go away. Tell your doctor or pharmacist right away if any of these side effects persist or worsen. · When rising gently from a sitting or laying posture, you can limit the danger of dizziness and lightheadedness. · If you have any very serious adverse effects, such as fainting, f